Erowid is personal opinions of drug users.

I don’t lecture about how much acid you should drop or how to prepare for a trip. I give a lecture on the cognitive and physiological changes the drug causes.

I use scientific resources.

Other people are welcome to use personal stories and opinions to inform themselves but we don’t use anecdotes in academia because none of them can be verified and are heavily subjective.

Doesn’t mean they don’t have value. Doesn’t mean the information is false.

It just means it’s not scientific.

After re checking this information, I believe I was confusing DMT and LSD properties of not being active when ingested.

I remembered DMT can’t be ingested but I was sure it was true for LSD. But I was mistaken. LSD is neutralized by base not acids.

Probably 15% of those don’t know what annex means

Novelty is a common effect that people don’t talk about much. Essentially it makes everything seem new and novel.

What’s interesting is, in the brain there is a specific spike in electrical activity (called event related potential, or ERP) that happens when you look at something new and unexpected. Some call it the novelty indicator. Designated P3a.

You can measure it with eeg equipment (electrodes on the scalp).

I’d be really interested to see if that ERP is happening more on LSD. It might shed more light on the mechanisms of the drug. If it doesn’t happen, then it would challenge the theory of what the P3a is.
I personally think LSD has a lot of potential to be used to research perception processing in the brain.

Too bad it’s basically impossible to get approval to use it for that reason.

https://en.wikipedia.org/wiki/P3a

Ah yes you are correct. I definitely mis reported the size. It’s 5x5mm

Most drugs/medicines are taken in higher doses because the body filters or neutralizes the compounds so much that only a small portion gets into the blood.

That’s still different.

Even if the total quantity of the drug is small in the system once it gets there, it’s not the same as how LSD works. The drug, likely because of its similarity to serotonin and size , is readily absorbed into the blood stream and passes the blood brain barrier easily. It is not filtered out to a small percentage of it’s original dose like most drugs/medicines.

You surely are aware of this ?

There are very few drugs that can work in small dosages like LSD. As I said, fentanyl is one.

Drugs like DMT /Ayahuasca also can’t be ingested unless they are mixed with a maoi inhibitor.

Most psychedelic research chemicals (nbome) are much different than lsd with different pharm and effect properties.

It’s possible that LSD is released more quickly on the tongue than nbome drugs. So as soon as it hits the tounge the drug is delivered. I don’t think there is research on this. But I’ll look into it. I do know that the first trip was caused by a small contact of the drug on someone’s hand. That the cleaned off immediately. And it was enough time to absorb a substantial amount of the drug.
I heard women would put on lipstick and smear LSD on the front and kiss police during protest to dose them. If That happened it might support a very fast delivery.
I can’t find the source right now to verify the story. I’ll keep looking. Maybe I have details wrong. Maybe it was Charles Manson instructing women to do this. Does this story sound familiar to anyone ? I’ll have to find the source and verify.

But my point is.

This idea that it’s not neutralized in the stomach is false. There is plenty of research on that.

Your stomach acid will definitely neutralize it. But after having it on your tongue for a while the drug has been deposited into your system.

You know there isn’t much in a single location aside from Wikipedia.

In textbooks I’ve come across , there is discussion of the pharmacology properties or a brief note about counter culture and general effects.

There is limited research on the drug as it’s been black listed for almost 50 years and even now, it’s primarily only researched for terminally ill people/mental health. Only a handful of those studies exist and none use double blind controls so the science quality is poor.

I myself am not convinced it has mental health benefits due to the way the drug works. It does however have strong suggestive effects meaning the drug itself promotes placebo/expectation effects.

The lecture I put together for my class (perception and sensation ) pulled info from a wide range of resources.

However there is one organization trying it’s best to do modern research and they have done some MRI studies. There was also a study on LSD and synesthesia which sheds a lot of light into the mechanisms. MAPS is the organization. https://maps.org/

They have videos on YouTube with researchers discussing the research and studies they have done. But they mostly focus (last few years at least) on it’s use in mental health.

The drug property information I know about is mostly pulled from old research from the 60s before the research bans. A lot was done on animals to understand dosage and half life. The cascade effects of how this drug works are still not really understood. We do know that the drug is similar in structure to serotonin. But there are still a lot of unknowns.

Let me dig around for my resource links. I have a few interesting studies I found when preparing the lecture, including the synesthesia one, and I’ll organize it all and I’ll put a link up to a g drive with it.

The lecture I did was 3 hrs long about hallucinations with a chunk dedicated to psychedelics. It did rely on other lecture materials to understand or otherwise id just put it up. (It was the final lecture for the class so it referred back multiple times to previous lessons). But maybe I can re-write it a bit. I’ve honestly been thinking of turning it into a video for a while because there are so few resources out there that review it more broadly. And a hell of a lot of misinformation about hallucinations and psychedelics.

Basically this lecture was on hallucinations and the primary causes and how each of these causes relies on the same root changes in brain processing.

For instance. You are driving on a country road at night. Vigilant to look for deer. Multiple times you were sure you saw an animal near the road but soon realized it was a fence post. Or an old glass bottle reflecting your headlamps. But for a split moment you did see an animal there before you corrected the perception.

What ultimately caused that is what causes hallucinations in other situations. Like schizophrenia and drug use.

So we circle around neuroscience, psychiatry, physiology, and pharmacology. As well as cultural impacts influencing the experience of hallucinations or psychedelics.

This is getting long. Apologies. The lecture is 3 hrs and relies on many other hours of information. It’s a big topic.

I mean it depends on the person and the dose on the tabs. Like most recreational illegal drugs, it’s hard to know how much is actually present on the tabs.

Many times drugs are diluted at various steps of transport and selling. Though it is harder to do that to a drug already on paper like this.

Lsd is often distributed and consumed via small paper squares called “tabs” that’s made on blotter paper. The paper is thick like cardstock. Sometimes with colorful psychedelic artwork printed on it.

The lsd is diluted in a solution and the paper is soaked in the solution.

The tiny microscopic lsd crystals deposit on the paper. The blotter paper is divided into 1cm squares. Correction. 5mm squares

Lsd is neutralized by many chemicals , including chlorine (found in tap water) and stomach enzymes. It cannot be swallowed and still have an effect. Unless mixed with other compounds

To take LSD, a person will place squares (typically one square is 1x 100ug dose) of the paper on the tounge or under it. And hold for about 15 minutes. Some people take more than one. It can’t kill you. But it can lead to accidents in high doses that can kill you. So it’s not risk free even if health risks are low.

Also I said ug. Not mg. The lsd drug is very unique in that it has high potency at micrograms. Fentanyl is another drug that has that property . But it is rare.

The lining of the mouth (mucus membranes) allows for easy transfer of the drug into the blood stream. That’s true for a lot of drugs actually.

This is why lsd has such a unique drug delivery method though. It can’t be swallowed and it should be used in very small doses.

Lsd is also very resistant to degredation. Oxygen, sunlight, and neutralizing chemicals like chlorine can degrade it. But if it’s stored properly it can last a very very long time. This is another rare property it has.

It’s also clear, tasteless, and no odor.

I’m a perception researcher and , of course, this would be a drug on my radar. So I know quite a bit about it. I’ve given a lecture on psychedelics. It’s a fascinating topic.

Also I’m generally interested in psycho-pharmacology because , well, it’s interesting.

If you want to learn more interesting facts about LSD and other psychedelics, ask away.

**Guy in picture has two tabs (squares of blotter paper) on his tongue and is wearing sunglasses because lsd dialates your pupils and makes your eyes sensitive to light.

Well Starbucks has been hardcore screwing over their workers so they are on the shit list.

I don’t know what the people are doing at the top.

I looked up his wiki. Now I feel bad saying he was sketchy. Maybe he was always just jittery from all the smoking. 3 packs a day, apparently.

And chronic pain from a serious back injury.

He founded a charity for the homeless.

Sounds like a decent person.

Maybe both. I can’t quite put my finger on it. But he seemed sketchy. Maybe the actor. Because it was consistent.

I never knew the backstory. Yikes.

I some times watch old retro shows on the free channels on TV. Put them on when I’m cleaning or something.

Caught a few episodes that way.

The thing about old TV shows is this. 1. They were presented as promoting morals and the better social norms.

I rember an episode of Dick van dike where his secretary argued she didn’t need to be paid as much as a man because she was just waiting to get married.

The episode was dick and some other guy doing secretary work for the day and messing it all up.

I guess showing it’s hard work. But at the end the woman was like. “But I don’t need paid better”.

And presented as totally respectful. So bizzare. The blatant sexism and toxic relationships always catches me off guard.

I think it was considered normal for couples to argue pretty much daily.

How many people grew up thinking that marriage is supposed to look like that ? My gawd. People must have been miserable.

Her name was Judith. Actually

I always got weird vibes from the bewitched guy. Like maybe he was a bad dude.

Anyone else ?

It’s not full adulting until you eat it dry for dinner.

I forgot that sometimes boys wore suits.

Like legit suits.

Can’t recall the last time I saw that in real life.

For some reason that stuck out to me the most.

I think my faith in their competency is a lot lower than yours.

But you may be right.

I’m sure a young man with vigor might be able to overcome some of those effects.

Especially after a few hours after taking the drug since its strong effects don’t last that long.

But the sexual physiological suppression is pretty strong and it’s also strong in women.

She ain’t no teenager with crazy hormones. Shea pushing menapause.

Things are already starting to work less dependably down there by that age.

And just to educate men who may not know this. It’s difficult and painful for a woman to have sex when she is not sexually aroused. It’s not just lubricant.

The genitals on women also go through physical changes. External genitalia plumps up. The muscles near the entrance relax and dialate. Lubricant forms all through the vagina increasing stretch. And also the muscles around the vagina relax.

When these things don’t happen (especially the muscle changes), sex will be very painful and unpleasant and can result in tears and rips.

*(There was a long discussion on reddit a few years back where I told men that pressuring their girl to have sex when she wasn’t in the mood will ultimately make her dislike you and not want to initiate sex or even be affectionate because it will be associated with pain. Pain that she will not tell you she is having because we have been conditioned In our society to not “ruin sex” for men by saying anything unsetting to them. Men’s pleasure is prioritized and ruining it for them will result in hostility from them (usually).

Many women feel like it’s easier to just give in than say no and risk the man getting mean or hostile. Or go around pouting. . So they do it even when they don’t want to. And it always hurts. It’s always unpleasant. - I got a lot of hate from men who did not like me telling them that they cause their partner pain when relentlessly asking for sex when their partner is not into it.

Men can’t be better partners if they pretend that this isn’t the reality of pressuring their partner for sex.

Those who acknowledge it are more likely to keep their partner and themselves happier.

Too much of sexual functioning for women is not taught and is unknown to most people, including women.

I mean they would check for bugs but radioactive?

I don’t think trump uses airport security checks.