It too me a while to work out why my Nextcloud stuff wasn’t working on my phone. It wasn’t until I went to http://duckdns.org on mobile data I saw the block. I had changed ISP from one with IPv6, which I had setup, to an ISP without it, and thought it might be that. But it was just coincidence.
I’ve written to O2 but I doubt they will change anything, so I’ll be changing network.
So heads up UK O2 self hosting people!
T-mobile was doing this in the US but only blocking certain ports when talking to my home server, might try putting it on a non-standard port as well and see if you can access the service then.
Oh I know some ports are ok. My SSH and WireGuard get through. Port 80 is redirected to a block page place holder and 443 is interfered with so SSL fails.